Description

3-Fluoro-2-(Trifluoromethyl)Benzoyl Chloride is a high-purity, multi-fluorinated benzoyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which introduces both fluorine and a trifluoromethyl group, enabling the precise modification of target molecules to enhance their metabolic stability, lipophilicity, and binding affinity. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, enhancing material properties like chemical resistance and thermal stability.
• Peptide & Protein Conjugation: Useful as an acylating agent for modifying biomolecules in biochemical research and diagnostic reagent development.
• Custom Synthesis & R&D: A versatile reagent for contract research organizations (CROs) and academic laboratories exploring new fluorinated chemical entities.

Basic Information

Item	Details
Product Name	3-Fluoro-2-(Trifluoromethyl)Benzoyl Chloride
CAS No.	261951-82-0
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	3-Fluoro-2-(trifluoromethyl)benzoyl chloride; 2-(Trifluoromethyl)-3-fluorobenzoyl chloride; 3-Fluoro-alpha,alpha,α-trifluoro-o-toluoyl chloride; Benzoyl chloride, 3-fluoro-2-(trifluoromethyl)-; 261951-82-0; o-Toluoyl chloride, 3-fluoro-alpha,alpha,α-trifluoro-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, GC, NMR, and IR spectroscopy. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.