Description

3-Fluoro-5-(Trifluoromethyl)Anisole is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its value lies in the unique electronic properties imparted by the fluorine and trifluoromethyl substituents, making it a critical intermediate for creating complex molecules with tailored functionality. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, as well as in materials science for specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence profiles.
• Liquid Crystal Materials: Acts as a core or side-chain component in the synthesis of fluorinated liquid crystals for high-performance displays and optical devices.
• Organic Electronics: Employed as a building block for electron-transport materials, semiconductors, and other components in OLEDs and organic photovoltaic cells.
• Specialty Polymer Modifier: Incorporated into polymer backbones to impart specific properties such as chemical resistance, thermal stability, or altered solubility.
• Cross-Coupling Reactions: Functions as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems in medicinal chemistry.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Anisole
CAS No.	261951-79-5
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	1-Fluoro-3-methoxy-5-(trifluoromethyl)benzene; 3-Fluoro-5-(trifluoromethyl)methoxybenzene; 3-Methoxy-5-(trifluoromethyl)fluorobenzene; Benzene, 1-fluoro-3-methoxy-5-(trifluoromethyl)-; 5-Trifluoromethyl-3-fluoroanisole; m-Fluoro-m-trifluoromethylanisole; 3-Fluoro-α,α,α-trifluoro-5-methoxytoluene
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.