Description

2-Fluoro-5-(trifluoromethyl)anisole is a high-value fluorinated aromatic building block, distinguished by its unique combination of fluorine and methoxy substituents. This compound is critical for introducing specific steric and electronic properties into advanced molecular architectures, enabling precise tuning of material and biological activity. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Material Science: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethyl)anisole
CAS No.	261951-78-4
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	1-Fluoro-2-methoxy-4-(trifluoromethyl)benzene; 2-Fluoro-5-(trifluoromethyl)methoxybenzene; 1-Methoxy-2-fluoro-4-(trifluoromethyl)benzene; 2-Fluoro-α,α,α-trifluoro-p-anisole; 5-(Trifluoromethyl)-2-fluoroanisole; Benzene, 1-fluoro-2-methoxy-4-(trifluoromethyl)-; 2-Fluoro-5-trifluoromethylanisole
EINECS	Contact for details

Quality Control

Every batch of our 2-Fluoro-5-(trifluoromethyl)anisole is manufactured and tested under a strict quality management system. We guarantee high-purity material suitable for demanding synthetic applications. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.420 - 1.430
Density (20°C)	1.35 - 1.45 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.