Description

3,4-Difluoro-5-(Trifluoromethyl)Benzamide is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its value lies in the unique reactivity and physicochemical properties imparted by its strategic fluorine and trifluoromethyl substituents, which are crucial for modulating the biological activity and stability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Research: Serves as a critical precursor in the synthesis of next-generation herbicides and fungicides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Material Science: Used in the research of advanced polymers and liquid crystals, where fluorinated aromatic units contribute to thermal stability and specific optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce a difluorotrifluoromethylphenyl moiety into complex molecules.
• Chemical Biology Probe Development: Utilized as a scaffold for creating molecular probes to study enzyme function and protein-ligand interactions due to its fluorine NMR handle.

Basic Information

Product Name	3,4-Difluoro-5-(Trifluoromethyl)Benzamide
CAS No.	261944-88-1
Molecular Formula	C8H4F5NO
Molecular Weight	225.12 g/mol
Synonyms	5-(Trifluoromethyl)-3,4-difluorobenzamide; 3,4-Difluoro-5-(trifluoromethyl)benzamide; Benzamide, 3,4-difluoro-5-(trifluoromethyl)-; 261944-88-1; 3,4-Difluoro-α,α,α-trifluoro-m-toluamide
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-(Trifluoromethyl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.