Description

2,3-Difluoro-4-Methylphenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the reactive nitrile group, enabling precise molecular modifications for creating complex target molecules. This intermediate is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a building block for fluorinated liquid crystal compounds used in high-performance display technologies.
• Functional Material Development: Employed in the synthesis of specialty polymers, organic semiconductors, and other advanced materials requiring specific electronic or steric properties.
• Chemical Research & Development: A valuable reagent for method development and exploring new reaction pathways in academic and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on various scales.

Basic Information

Product Name	2,3-Difluoro-4-Methylphenylacetonitrile
CAS No.	261944-01-8
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	2,3-Difluoro-4-methylbenzyl cyanide; (2,3-Difluoro-4-methylphenyl)acetonitrile; 2-(2,3-Difluoro-4-methylphenyl)acetonitrile; 4-Methyl-2,3-difluorobenzyl cyanide; α-Cyano-2,3-difluoro-4-methyltoluene; 2,3-Difluoro-p-tolylacetonitrile; 261944-01-8 (CAS)
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Methylphenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Recommended storage temperature is between 2°C and 8°C for long-term stability, although the product is typically stable at controlled room temperature for shorter periods. Keep away from strong oxidizing agents, strong bases, and moisture. The original container is the optimal storage vessel.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.