Description

2,3-Difluoro-4-Methylphenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the reactive acetic acid moiety, enabling precise molecular modifications to enhance the properties of target compounds. This intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with improved metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-inflammatory, and oncology applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethylphenyl moiety can improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays, leveraging its aromatic and fluorine components.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials due to its electron-withdrawing fluorinated aromatic system.
• Chemical Research & Development: A versatile building block for exploring new chemical entities and reaction pathways in academic and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific fluorinated target molecules.

Basic Information

Product Name	2,3-Difluoro-4-Methylphenylacetic Acid
CAS No.	261763-47-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	(2,3-Difluoro-4-methylphenyl)acetic acid; 2-(2,3-Difluoro-4-methylphenyl)acetic acid; α-(2,3-Difluoro-p-tolyl)acetic acid; 2,3-Difluoro-4-methylbenzeneacetic acid; 261763-47-7; 2,3-Difluoro-4-methylphenyl-acetic acid; 4-Methyl-2,3-difluorophenylacetic acid
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-4-Methylphenylacetic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.