Description

3-Chloro-2-Fluoro-5-(Trifluoromethyl)Anisole is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which introduces multiple halogen and alkoxy functionalities critical for modulating the electronic and steric properties of target molecules. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and halogen groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers and ligands used in the development of advanced polymers, liquid crystals, and catalytic systems.
• Chemical Biology & Diagnostics: Employed as a building block for fluorescent probes, molecular tags, and other diagnostic tools due to its derivatizable aromatic core.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-(Trifluoromethyl)Anisole
CAS No.	261763-01-3
Molecular Formula	C8H5ClF4O
Molecular Weight	228.57 g/mol
Synonyms	1-Chloro-2-fluoro-3-methoxy-5-(trifluoromethyl)benzene; 2-Fluoro-3-chloro-5-(trifluoromethyl)anisole; 3-Chloro-2-fluoro-5-(trifluoromethyl)methoxybenzene; Benzene, 1-chloro-2-fluoro-3-methoxy-5-(trifluoromethyl)-; 3-Chloro-2-fluoro-5-trifluoromethylanisole; 2-Fluoro-3-chloro-α,α,α-trifluoro-5-methoxytoluene
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reproducible results in sensitive R&D and scale-up environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.