Description

2'-Chloro-6'-Fluoro-3'-Methylacetophenone is a high-purity, multi-functional aromatic ketone building block of significant importance in advanced organic synthesis. Its precise halogen and methyl substitution pattern makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging its halogenated aromatic structure.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where its specific substitution pattern influences material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, Friedel-Crafts acylation, and other transformations to introduce functionalized acetophenone motifs.
• Chemical Research & Development: A valuable standard and starting material in academic and industrial R&D labs for methodological studies and library synthesis.

Basic Information

Product Name	2'-Chloro-6'-Fluoro-3'-Methylacetophenone
CAS No.	261762-63-4
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	1-(2-Chloro-6-fluoro-3-methylphenyl)ethanone; 2-Chloro-6-fluoro-3-methylacetophenone; 2'-Chloro-6'-fluoro-3'-methylacetophenone; 1-Acetyl-2-chloro-6-fluoro-3-methylbenzene; α-Chloro-α-fluoro-α-methylacetophenone derivative; 2-Chloro-6-fluoro-3-methylphenyl methyl ketone; 3-Methyl-2-chloro-6-fluoroacetophenone
EINECS	Contact for details

Quality Control

Our production of 2'-Chloro-6'-Fluoro-3'-Methylacetophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.