Description

3-Chloro-2,6-Difluorobenzamide is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoro and chloro substituents contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic materials with unique electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic and Industrial R&D: Utilized in research laboratories for methodological studies in cross-coupling reactions and nucleophilic aromatic substitution.

Basic Information

Product Name	3-Chloro-2,6-Difluorobenzamide
CAS No.	261762-41-8
Molecular Formula	C7H4ClF2NO
Molecular Weight	191.56 g/mol
Synonyms	2,6-Difluoro-3-chlorobenzamide; 3-Chloro-2,6-difluorobenzoic acid amide; Benzamide, 3-chloro-2,6-difluoro-; 261762-41-8; 3-Chloro-2,6-difluorobenzamide; 2,6-Difluoro-3-chlorobenzoamide
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,6-Difluorobenzamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each shipment, supporting compliance with cGMP and ICH guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.