Description

3-Chloro-2,6-Difluoroanisole is a high-purity fluorinated anisole derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique substitution pattern, which enables precise structural modifications in complex molecule construction. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to build active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethoxy or related aromatic ether motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require halogenated anisole structures.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic compounds used in electronic display technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized anisole units.
• Chemical Research & Development: A valuable tool for medicinal chemistry and material science research to explore new chemical entities and properties.

Basic Information

Product Name	3-Chloro-2,6-Difluoroanisole
CAS No.	261762-38-3
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	1-Chloro-2,6-difluoro-3-methoxybenzene; 2,6-Difluoro-3-chloroanisole; Benzene, 1-chloro-2,6-difluoro-3-methoxy-; 3-Chloro-2,6-difluorophenyl methyl ether; Methyl 3-chloro-2,6-difluorophenyl ether
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,6-Difluoroanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.