Description

5-Bromo-2,3-difluoroanisole is a high-purity, multi-functional aromatic building block characterized by its bromine and fluorine substituents on a methoxybenzene core. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, enabling the introduction of halogenated motifs critical for modulating the electronic and steric properties of target molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates where the bromine atom serves as a handle for further cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity often associated with difluoromethoxy and bromoaryl groups.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated aromatic compounds for electronic materials, where such substitutions fine-tune liquid crystalline phases or optoelectronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, facilitating rapid diversification in medicinal chemistry libraries.
• Functional Polymer Monomers: Employed in the synthesis of specialty polymers and dendrimers requiring halogenated aromatic monomers for specific thermal or chemical resistance.

Basic Information

Product Name	5-Bromo-2,3-difluoroanisole
CAS No.	261762-35-0
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-methoxybenzene; 2,3-Difluoro-5-bromoanisole; Benzene, 1-bromo-2,3-difluoro-4-methoxy-; 4-Methoxy-2,3-difluorobromobenzene; 5-Bromo-2,3-difluoromethoxybenzene; 2,3-Difluoro-5-bromo-1-methoxybenzene; Anisole, 5-bromo-2,3-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2,3-difluoroanisole is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (Area %)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.