Description

4,5,5,5-Tetrafluoro-4-(trifluoromethoxy)pent-2-enoic acid is a highly fluorinated, unsaturated carboxylic acid building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a reactive α,β-unsaturated acid moiety adjacent to a perfluorinated ether chain, makes it a valuable precursor for introducing fluorinated motifs into target molecules. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides where fluorine substitution improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or modifier for creating specialty polymers with unique surface properties, chemical resistance, and low dielectric constants.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for advanced display materials and dielectric fluids.
• Organic Synthesis Reagent: A versatile reagent for introducing the 4,5,5,5-tetrafluoro-4-(trifluoromethoxy)pent-2-enoyl group via condensation or conjugate addition reactions.
• Fluorinated Surfactant Research: Acts as a starting material for creating novel fluorosurfactants with potential applications in coatings and fire-fighting foams.

Basic Information

Product Name	4,5,5,5-Tetrafluoro-4-(trifluoromethoxy)pent-2-enoic Acid
CAS No.	261760-20-7
Molecular Formula	C6H3F7O3
Molecular Weight	256.08 g/mol
Synonyms	4,5,5,5-Tetrafluoro-4-(trifluoromethoxy)-2-pentenoic Acid; 4-(Trifluoromethoxy)-4,5,5,5-tetrafluoropent-2-enoic Acid; 2-Pentenoic acid, 4,5,5,5-tetrafluoro-4-(trifluoromethoxy)-; Perfluorinated Unsaturated Acid Building Block; TFMPA Intermediate
EINECS	Contact for details

Quality Control

Our production of 4,5,5,5-Tetrafluoro-4-(trifluoromethoxy)pent-2-enoic acid adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and accompanied by a comprehensive Certificate of Analysis (COA). We support cGMP and ISO 9001 compliant manufacturing practices, and our quality systems are designed to meet the exacting standards of pharmaceutical and agrochemical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its strong acid/organic solvent nature, keep away from incompatible materials such as strong bases, oxidizing agents, and amines. Handle and store under an inert atmosphere if prolonged storage is required to minimize potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.