Description

3,4,4,4-Tetrafluoro-3-Trifluoromethoxy-1-Butyne is a highly fluorinated alkyne building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a terminal alkyne and a trifluoromethoxy group, makes it a valuable precursor for introducing fluorinated motifs into complex molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries. It enables the synthesis of novel compounds with potential applications in drug discovery and the development of specialty materials with tailored properties.

Application

• Pharmaceutical Intermediate: Serves as a key fluorinated synthon for the discovery and development of new active pharmaceutical ingredients (APIs), particularly for introducing metabolic stability and modulating lipophilicity.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where fluorine atoms can enhance biological activity and environmental persistence.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers, coatings, and electronic materials with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Development: Employed to create fluorinated components for advanced display technologies, improving performance characteristics like dielectric anisotropy and stability.
• Fluorinated Surfactant & Lubricant Synthesis: A building block for creating high-performance surfactants and lubricants with exceptional thermal and chemical stability.
• Click Chemistry Reagent: Its terminal alkyne group makes it suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create complex fluorinated architectures.

Basic Information

Product Name	3,4,4,4-Tetrafluoro-3-Trifluoromethoxy-1-Butyne
CAS No.	261760-14-9
Molecular Formula	C5HF7O
Molecular Weight	210.05 g/mol
Synonyms	1-Butyne, 3,4,4,4-tetrafluoro-3-(trifluoromethoxy)-; 3-(Trifluoromethoxy)-3,4,4,4-tetrafluoro-1-butyne; 3,4,4,4-Tetrafluoro-3-(trifluoromethoxy)-1-butyne; Perfluoro(3-methoxy-1-buten-3-yl)acetylene; TFMO-Tetrafluoro Butyne; Fluorinated Trifluoromethoxy Alkyne; HFPO Acetylene Derivative
EINECS	Contact for details

Quality Control

Our 3,4,4,4-Tetrafluoro-3-Trifluoromethoxy-1-Butyne is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including GC, NMR, and FTIR, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support our clients' regulatory needs and can supply material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, ideally at temperatures between 2°C and 8°C to minimize evaporation and degradation. Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider keeping the container under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.55 g/mL
Boiling Point	~85-90°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.