Description

2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Prop-2-Enoic Acid is a specialized Fmoc-protected amino acid derivative, a crucial building block in modern solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled and efficient incorporation of dehydroalanine analogs into peptide chains, which is essential for creating structurally diverse and biologically active compounds. This high-purity intermediate is indispensable for research and development laboratories in the pharmaceutical, biotechnology, and agrochemical sectors focused on novel peptide-based therapeutics and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled introduction of dehydroalanine residues into custom peptide sequences.
• Pharmaceutical Research: Used in the R&D of novel peptide drugs, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Chemical Biology & Proteomics: Serves as a building block for synthesizing activity-based probes and peptide substrates to study enzyme function and protein-protein interactions.
• Agrochemical Development: Employed in the synthesis of bioactive peptide mimetics for potential crop protection agents.
• Material Science: Can be utilized to create functionalized peptides for self-assembling biomaterials and peptide-polymer conjugates.
• Process Development: Used in scaling up the production of specific therapeutic peptides under GMP conditions.

Basic Information

Product Name	2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Prop-2-Enoic Acid
CAS No.	261522-33-2
Molecular Formula	C18H15NO4
Molecular Weight	309.32 g/mol
Synonyms	Fmoc-dehydroalanine; Fmoc-Dha-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3-didehydroalanine; N-Fmoc-2,3-didehydroalanine; 2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Acrylic Acid; Fmoc-δAla-OH; (E)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Prop-2-Enoic Acid; Fmoc-α,β-Dehydroalanine
EINECS	Contact for details

Quality Control

Our 2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Prop-2-Enoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis where applicable. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.