Description

Fulvestrant 17-β-D-Glucuronide CAS NO 261506-28-9 is a key glucuronide metabolite of the selective estrogen receptor degrader (SERD) Fulvestrant. This compound is of significant value as a reference standard and analytical tool in pharmaceutical research and development. It is primarily needed by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in metabolism studies, bioanalytical method development, and regulatory compliance testing for oncology therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantitative and qualitative analysis of Fulvestrant and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and pharmacokinetic profile of Fulvestrant.
• Bioanalytical Method Development: Serves as a critical calibrator and quality control sample in developing and validating LC-MS/MS and HPLC methods for clinical and preclinical studies.
• Impurity Profiling: Employed to identify, characterize, and quantify related substances and degradation products in Fulvestrant drug substance and product formulations.
• Regulatory Submissions: Provides essential data to support Investigational New Drug (IND) and New Drug Application (NDA) filings with regulatory bodies like the FDA and EMA.

Basic Information

Product Name	Fulvestrant 17-β-D-Glucuronide
CAS No.	261506-28-9
Molecular Formula	C32H43FO8S
Molecular Weight	606.75 g/mol
Synonyms	Fulvestrant 17-Glucuronide; Fulvestrant Glucuronide; ICI 182,780 Glucuronide; 7α-[9-(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17β-diol 17-β-D-Glucuronide; (7α,17β)-7-[[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol 17-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Fulvestrant 17-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.