Description

Fulvestrant-3-Sulfate is a key sulfated metabolite of the selective estrogen receptor degrader (SERD) Fulvestrant. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced oncology research and bioanalytical method development for hormone receptor-positive breast cancer therapies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of Fulvestrant and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, bioavailability, and clearance mechanisms of Fulvestrant in preclinical and clinical research.
• Bioanalytical Method Development: Essential for developing and validating sensitive LC-MS/MS or HPLC methods to monitor drug and metabolite levels in plasma, serum, or tissue samples.
• Impurity Profiling: Employed as an impurity marker in the quality control of Fulvestrant active pharmaceutical ingredient (API) to ensure product purity and safety.
• Mechanistic Research: Aids in studying the structure-activity relationship (SAR) of sulfated steroid derivatives and their role in estrogen receptor signaling pathways.

Basic Information

Product Name	Fulvestrant-3-Sulfate
CAS No.	261506-26-7
Molecular Formula	C32H47F5O6S
Molecular Weight	654.78 g/mol
Synonyms	Fulvestrant 3-Sulfate; Fulvestrant Sulfate; 7α-[9-(4,4,5,5,5-Pentafluoropentylsulfinyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol 3-Sulfate; ICI 182,780 Sulfate; Faslodex Sulfate Metabolite; (7α,17β)-7-{9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol 3-Sulfate
EINECS	Contact for details

Quality Control

Our Fulvestrant-3-Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry and NMR, to ensure it meets the high standards required for research and reference applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.