Description

Boc-2,5-Dimethy-D-Phenylalanine is a protected, non-natural amino acid derivative of significant importance in advanced organic synthesis. This compound is valued for its role as a key chiral building block in the construction of complex peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptide libraries. Its specific stereochemistry and protective group make it essential for precise molecular design.

Application

• Pharmaceutical Intermediates: A critical chiral synthon in the research and development of new drug candidates, particularly for metabolic and neurological disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a dimethylated phenylalanine residue with defined D-configuration.
• Protease Inhibitor Design: Serves as a core structural component in the design of inhibitors targeting specific enzyme active sites.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the structure-activity relationships (SAR) of peptide-based molecules.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Agrochemical Research: Potential application as a building block for novel, bioactive compounds with specific chiral requirements.

Basic Information

Product Name	Boc-2,5-Dimethy-D-Phenylalanine
CAS No.	261380-33-0
Molecular Formula	C16H23NO4
Molecular Weight	293.36 g/mol
Synonyms	(2R)-2-[(tert-Butoxycarbonyl)amino]-3-(2,5-dimethylphenyl)propanoic acid; Boc-D-2,5-Dimethyl-Phe-OH; N-Boc-2,5-Dimethyl-D-phenylalanine; N-(tert-Butoxycarbonyl)-2,5-dimethyl-D-phenylalanine; tert-Butyl (R)-2-(2,5-dimethylphenyl)-1-carboxyethylcarbamate; Boc-2,5-Dimethyl-D-Phe; Boc-D-2,5-Dimethylphenylalanine
EINECS	Contact for details

Quality Control

Our Boc-2,5-Dimethy-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.