Description

(R)-n-Boc-2-Bromophenylalanine CAS NO 261360-76-3 is a high-purity, non-natural amino acid derivative featuring a chiral center and a bromine substituent on the aromatic ring. This compound is a critical chiral building block in modern organic synthesis, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds where structural precision is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for peptide drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a brominated phenylalanine residue, allowing for further site-specific functionalization via cross-coupling reactions.
• Chemical Biology & Proteomics: Serves as a building block for synthesizing peptide probes, inhibitors, and substrates to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in the asymmetric synthesis of more complex chiral molecules due to its defined (R)-configuration.
• Material Science Research: Can be utilized in the development of functionalized polymers or advanced materials where bromine acts as a handle for further modification.

Basic Information

Product Name	(R)-n-Boc-2-Bromophenylalanine
CAS No.	261360-76-3
Molecular Formula	C₁₄H₁₈BrNO₄
Molecular Weight	344.20 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(2-bromophenyl)propanoic acid; (R)-3-(2-Bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Boc-2-Br-Phe-OH (R-isomer); (R)-Boc-2-Bromo-phenylalanine; (R)-N-Boc-2-Bromophenylalanine; tert-Butyl (R)-(2-bromobenzyl)-L-alaninate N-carboxylate; (R)-N-(tert-Butoxycarbonyl)-2-bromophenylalanine
EINECS	Contact for details

Quality Control

Our (R)-n-Boc-2-Bromophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.