Description

Boc-p-Isopropylphenyl-L-Alanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is a critical building block for medicinal chemists, enabling the precise construction of complex peptide chains with enhanced stability and specific biological activity. It is primarily utilized in pharmaceutical research and development for creating novel therapeutic peptides, peptidomimetics, and as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the p-isopropylphenylalanine residue with N-terminal Boc protection.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop peptidomimetics and bioactive compounds with tailored properties.
• Bioconjugation: Serves as a modified amino acid for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology Probes: Utilized in the development of chemical probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	Boc-p-Isopropylphenyl-L-Alanine
CAS No.	261360-70-7
Molecular Formula	C₁₇H₂₅NO₄
Molecular Weight	307.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-4-isopropyl-L-phenylalanine; Boc-4-isopropyl-L-Phe-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[4-(propan-2-yl)phenyl]propanoic acid; Boc-L-p-isopropylphenylalanine; N-Boc-4-isopropyl-L-phenylalanine; tert-Butyloxycarbonyl-p-isopropyl-L-phenylalanine; Boc-Phe(4-iPr)-OH; BOC-PHE(4-IPR)-OH
EINECS	Contact for details

Quality Control

Our Boc-p-Isopropylphenyl-L-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.