Description

Rizatriptan N10-Oxide is a key pharmaceutical intermediate and metabolite of the active drug substance Rizatriptan. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development and quality control of migraine therapeutics.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of Rizatriptan and its related compounds.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies to understand the drug's metabolic pathway.
• Analytical Research: Serves as a standard in HPLC, LC-MS, and other chromatographic methods for method development and validation.
• Impurity Profiling: Essential for identifying and quantifying process-related impurities and degradation products in Rizatriptan API batches.
• Pharmacology Studies: Employed in preclinical and clinical research to investigate the safety and efficacy profiles of drug metabolites.
• Regulatory Compliance: Supports regulatory filings (e.g., with FDA, EMA) by providing necessary data on drug impurities and degradation products.

Basic Information

Product Name	Rizatriptan N10-Oxide
CAS No.	260435-42-5
Molecular Formula	C15H19N5O2
Molecular Weight	301.35 g/mol
Synonyms	N10-Oxide of Rizatriptan; Rizatriptan Impurity F (EP); Rizatriptan N-Oxide; 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole N10-Oxide; MK-0462 N-Oxide; Rizatriptan Related Compound F; 1H-Indole, 3-[2-(dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-, 10-oxide
EINECS	Contact for details

Quality Control

Our Rizatriptan N10-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the requirements for use as a reference standard. Specifications are aligned with major pharmacopoeial guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.