Description

5-(9-Fluorenylmethyloxycarbonyl-Amino)-3-Oxapentanoic Acid is a specialized Fmoc-protected amino acid derivative, serving as a crucial building block in solid-phase peptide synthesis (SPPS). Its core value lies in providing a protected amino group and a flexible, hydrophilic linker, enabling the controlled assembly of complex peptides and peptide conjugates. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, where precise molecular construction is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of amino acids to construct target peptide sequences.
• Bioconjugation and Linker Chemistry: Used to attach peptides, drugs, or probes to other biomolecules, nanoparticles, or surfaces via its carboxylic acid functionality.
• Pharmaceutical Research & Development: Critical for synthesizing peptide-based drug candidates, including those for metabolic disorders, oncology, and infectious diseases.
• Peptide Mimetic Design: Incorporates the 3-oxapentanoic acid spacer to modulate the pharmacokinetic properties and stability of therapeutic peptides.
• Combinatorial Chemistry Libraries: Serves as a versatile scaffold for generating diverse libraries of compounds for high-throughput screening.
• Diagnostic Reagent Production: Employed in the synthesis of peptide antigens, enzyme substrates, or labeled probes for diagnostic assays.

Basic Information

Product Name	5-(9-Fluorenylmethyloxycarbonyl-Amino)-3-Oxapentanoic Acid
CAS No.	260367-12-2
Molecular Formula	C20H21NO5
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-8-amino-3,6-dioxaoctanoic acid; Fmoc-Ado-OH; Fmoc-N-amido-PEG2-acid; 2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy}acetic acid; N-α-Fmoc-8-amino-3,6-dioxaoctanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-8-amino-3,6-dioxaoctanoic acid; Fmoc-NH-PEG2-CH2COOH
EINECS	Contact for details

Quality Control

Our 5-(9-Fluorenylmethyloxycarbonyl-Amino)-3-Oxapentanoic Acid is manufactured under strict quality systems to ensure consistency and reliability for critical research and production applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); containers should be kept sealed under inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.