Description

(S)-(-)-Desmethylsibutramine Hcl CAS NO 259731-39-0 is a high-purity chiral intermediate and active pharmaceutical ingredient (API) metabolite. This compound is critical for pharmaceutical research and development, particularly in the study of metabolic pathways and the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in advanced drug development and quality control.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of advanced pharmaceutical compounds and active metabolites.
• Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the pharmacokinetics, pharmacodynamics, and metabolic pathways of related pharmaceutical agents.
• Process Chemistry: Serves as a critical intermediate in the development and scale-up of efficient, asymmetric synthetic routes for target molecules.
• Impurity Profiling: Employed as a marker for identifying and quantifying related substances and degradation products in finished drug products and APIs.

Basic Information

Product Name	(S)-(-)-Desmethylsibutramine Hcl
CAS No.	259731-39-0
Molecular Formula	C16H26ClN
Molecular Weight	267.84 g/mol
Synonyms	(1S)-1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride; (S)-Desmethylsibutramine Hydrochloride; (S)-M1 Metabolite of Sibutramine HCl; (S)-N-Desmethylsibutramine HCl; BTS 54 505; (S)-(-)-N-Desmethylsibutramine Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(-)-Desmethylsibutramine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.