Description

1-Bromo-2-(Difluoromethoxy)-3-Nitro-Benzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is valued for its unique combination of bromo, difluoromethoxy, and nitro substituents, which enable precise molecular modifications and the introduction of key functional groups. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a specialized monomer or building block for developing advanced polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Nitro Group Reduction: The nitro group can be selectively reduced to an amine, providing a versatile handle for further derivatization into amides, sulfonamides, or heterocycles.
• Fluorine Chemistry Studies: An important compound for investigating the effects of the difluoromethoxy group on chemical reactivity and physical properties in medicinal and agrochemical design.

Basic Information

Product Name	1-Bromo-2-(Difluoromethoxy)-3-Nitro-Benzene
CAS No.	259243-49-7
Molecular Formula	C7H4BrF2NO3
Molecular Weight	268.02 g/mol
Synonyms	2-Bromo-1-(difluoromethoxy)-3-nitrobenzene; 3-Nitro-2-bromophenyl difluoromethyl ether; Benzene, 1-bromo-2-(difluoromethoxy)-3-nitro-; 2-Bromo-α,α-difluoro-6-nitroanisole; 1-Bromo-2-(difluoromethoxy)-3-nitrobenzene; 2-(Difluoromethoxy)-1-bromo-3-nitrobenzene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-(Difluoromethoxy)-3-Nitro-Benzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and process development. Certificates of Analysis (COA) with detailed results from HPLC, NMR, and GC-MS are provided to guarantee reliable quality and traceability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.