Description

4-Fluoro-2-Hydroxyphenylboronic Acid is a multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables efficient cross-coupling reactions, and the phenolic hydroxyl group offers a versatile handle for further derivatization. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel fluorinated biaryl compounds with potential therapeutic activity.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, ligands, and organic frameworks (MOFs/COFs).
• Chemical Research: Employed as a versatile reagent in academic and industrial R&D for constructing complex molecular architectures.
• Diagnostic Reagent Development: Potential use in the synthesis of probes and sensors that utilize boronic acid-diol interactions for analyte detection.

Basic Information

Product Name	4-Fluoro-2-Hydroxyphenylboronic Acid
CAS No.	259209-20-6
Molecular Formula	C6H6BFO3
Molecular Weight	155.92 g/mol
Synonyms	(4-Fluoro-2-hydroxyphenyl)boronic acid; 2-Hydroxy-4-fluorophenylboronic acid; 4-Fluoro-2-hydroxybenzeneboronic acid; 4-Fluoro-2-hydroxy-phenylboronic acid; 4-Fluoro-2-hydroxybenzeneboronic acid pinacol ester (common derivative); 4-Fluoro-2-hydroxybenzeneboronic acid MIDA ester (common derivative); 2-Borono-5-fluorophenol; 4-Fluoro-2-hydroxybenzeneboronic acid, 95%
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Hydroxyphenylboronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.