Description

n-Fmoc-4-Chlorobenzyl-Glycine CAS NO 258332-42-2 is a protected amino acid derivative, specifically an Fmoc-protected glycine with a 4-chlorobenzyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates targeting various diseases.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive molecules.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Academic Research: Fundamental studies in peptide structure, function, and folding mechanisms.
• Production of Specialty Peptides: Manufacture of peptides for diagnostic kits, reagents, and standards.

Basic Information

Product Name	n-Fmoc-4-Chlorobenzyl-Glycine
CAS No.	258332-42-2
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	Fmoc-4-Cl-Bzl-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-chloro-L-phenylalanine; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-chloro-L-phenylalanyl-; Fmoc-4-chloro-L-phenylalanyl-glycine; N-Fmoc-4-chlorobenzylglycine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-chlorophenyl)propanoic acid; Fmoc-Phe(4-Cl)-OH (commonly used for the phenylalanine analog, check specific structure); Fmoc-4-Cl-Phg-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Chlorobenzyl-Glycine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.