Description

8-Amino[1”-(N”-Dansyl)-4”-Aminobutyl]-5'-(1-Aziridinyl)-5'-Deoxy Adenosine is a sophisticated, multi-functional nucleoside derivative designed for advanced biochemical research and pharmaceutical development. This compound matters as a critical building block for creating targeted molecular probes and therapeutic agents, combining the fluorescence of a dansyl group with the alkylating potential of an aziridine moiety. It is primarily needed by researchers and developers in the fields of medicinal chemistry, oncology research, and molecular biology for applications in drug discovery, DNA alkylation studies, and fluorescence-based assay development.

Application

• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate in the synthesis of novel nucleoside-based therapeutics, particularly for targeting DNA in cancer research.
• Biochemical Probes: Used to develop fluorescently-labeled probes for studying enzyme mechanisms, nucleic acid interactions, and cellular uptake pathways.
• Oncology Research: The aziridinyl group facilitates its use in studying DNA cross-linking agents and developing potential alkylating chemotherapeutic agents.
• Photophysical Studies: The dansyl fluorophore enables applications in fluorescence spectroscopy, FRET (Förster Resonance Energy Transfer) assays, and sensor development.
• Antiviral/Anticancer Agent Development: Explored as a precursor for modified nucleosides with potential biological activity against viral replication or tumor cell proliferation.
• Bioconjugation: The reactive amino and aziridinyl groups allow for site-specific conjugation to proteins, peptides, or other biomolecules.

Basic Information

Product Name	8-Amino[1”-(N”-Dansyl)-4”-Aminobutyl]-5'-(1-Aziridinyl)-5'-Deoxy Adenosine
CAS No.	256953-68-1
Molecular Formula	C₃₀H₄₀N₁₀O₅S
Molecular Weight	652.79 g/mol
Synonyms	5'-Deoxy-5'-(1-aziridinyl)-8-[4-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]butyl]amino]adenine; Dansyl-aminobutyl-8-amino-5'-deoxy-5'-(aziridin-1-yl)adenosine; N⁶-(4-((5-(Dimethylamino)naphthalene-1-sulfonamido)butyl)-5'-deoxy-5'-(aziridin-1-yl)adenosine; 8-(4-(Dansylamino)butylamino)-5'-(1-aziridinyl)-5'-deoxyadenosine; Aziridinyl Dansyl Adenosine Derivative; DNA Alkylating Fluorescent Probe; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Amino[1”-(N”-Dansyl)-4”-Aminobutyl]-5'-(1-Aziridinyl)-5'-Deoxy Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While produced to meet the exacting standards of research and development, specifications can be customized to align with specific project requirements, including compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.