Description

(4-Aminomethylcyclohexylmethyl)-Carbamic Acid tert-Butyl Ester Hydrochloride And Enantiomer is a high-purity, enantiomerically defined chemical intermediate of significant importance in advanced organic synthesis. Its value lies in its protected amine functionality and chiral cyclohexylmethyl backbone, which are critical for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Peptidomimetic Research: Used to introduce constrained, chiral cyclohexyl-based scaffolds into peptide analogs to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by providing a versatile, protected amine handle for further functionalization.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D pipelines.
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for studying biological pathways and target engagement.

Basic Information

Product Name	(4-Aminomethylcyclohexylmethyl)-Carbamic Acid tert-Butyl Ester Hydrochloride And Enantiomer
CAS No.	256649-59-9
Molecular Formula	C14H28N2O2 • HCl
Molecular Weight	292.85 g/mol (Free base: 256.39 g/mol)
Synonyms	tert-Butyl N-[(4-(aminomethyl)cyclohexyl)methyl]carbamate hydrochloride; (4-(Aminomethyl)cyclohexyl)methylcarbamic acid tert-butyl ester hydrochloride; Boc-Amc-OH.HCl; N-Boc-1,4-cyclohexanedimethanamine hydrochloride; 4-(Aminomethyl)cyclohexanemethylamine, N-Boc-protected, hydrochloride; (4-Aminomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester hydrochloride; UNII-9I4N6F8U4F; (1r,4r)-4-(Aminomethyl)cyclohexyl)methylcarbamic acid tert-butyl ester hydrochloride (for specific enantiomer)
EINECS	Contact for details

Quality Control

Our production of (4-Aminomethylcyclohexylmethyl)-Carbamic Acid tert-Butyl Ester Hydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure compliance with exacting research and development standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.