Description

(1-Boc-Piperidin-4-Yl)Acetonitrile is a versatile and high-purity Boc-protected piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex nitrogen-containing heterocycles, which are core scaffolds in modern pharmaceutical discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of piperidine-based drug candidates, including kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides that require a functionalized piperidine moiety.
• Peptidomimetics & PROTACs: Used in the design and synthesis of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for biological target identification and validation.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	(1-Boc-Piperidin-4-Yl)Acetonitrile
CAS No.	256411-39-9
Molecular Formula	C₁₂H₂₀N₂O₂
Molecular Weight	224.30 g/mol
Synonyms	4-(Cyanomethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate; 1-Boc-4-(cyanomethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(cyanomethyl)piperidine; N-Boc-4-piperidineacetonitrile; Boc-Pip(4-CN)-OH; (1-Boc-4-piperidyl)acetonitrile; 4-(Cyanomethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (1-Boc-Piperidin-4-Yl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.