Description

(R)-(+)-2,2'-Bis[Di(3,4,5-Trimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand of significant importance in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the synthesis of complex chiral molecules. This product is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and effective ligands for developing new synthetic routes and scaling up production.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling, allylic alkylation, and other C-C bond-forming reactions to create stereogenic centers with high fidelity.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and more.
• Agrochemical Product Development: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators where biological activity is often enantiomer-specific.
• Fine Chemical and Flavor/Fragrance Manufacturing: Enables the cost-effective production of high-value chiral compounds used in flavors, fragrances, and advanced materials.
• Catalyst Screening and Development: Serves as a benchmark or starting point ligand in high-throughput screening and catalyst optimization programs within R&D laboratories.

Basic Information

Item	Details
Product Name	(R)-(+)-2,2'-Bis[Di(3,4,5-Trimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	256390-47-3
Molecular Formula	C58H62O14P2
Molecular Weight	1021.05 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-3,3',5,5'-Tetra-tert-butyl-4,4'-di-3,5-xylyl-SEGPHOS (common trade name); (R)-(+)-2,2'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-6,6'-dimethoxy-1,1'-biphenyl; (R)-DTBM-Segphos; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-DTBM-SegPhos ligand; (R)-SEGPHOS derivative; (R)-DTBM-SEGPHOS ligand
EINECS	Contact for details

Quality Control

Our (R)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance. Each lot undergoes comprehensive analysis, including HPLC for purity and chiral assay, NMR for structural confirmation, and specific tests for moisture and residual solvents. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality management systems and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to light and oxygen, it is recommended to store the product under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Keep the container sealed in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.