Description

(S)-(-)-2,2'-Bis[Di(3,4,5-Trimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand essential for asymmetric synthesis. This compound matters because it enables highly selective catalytic transformations, crucial for producing enantiomerically pure intermediates in pharmaceutical and fine chemical manufacturing. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance ligands for complex hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with excellent stereocontrol.
• Agrochemical Research: Employed in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Production: For the manufacture of specialty chemicals, flavors, and fragrances where stereochemistry is critical.

Basic Information

Product Name	(S)-(-)-2,2'-Bis[Di(3,4,5-Trimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	256235-61-7
Molecular Formula	C58H62O14P2
Molecular Weight	1021.04 g/mol
Synonyms	(S)-(-)-DTBM-SEGPHOS; (S)-DTBM-SEGPHOS; (S)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (S)-(-)-2,2'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-6,6'-dimethoxy-1,1'-biphenyl; (S)-DTBM-SEGPHOS ligand; SEGPHOS-DTBM; (S)-(-)-DTBM-SEGPHOS (min. 97%); (S)-DTBM-SEGPHOS, 97%
EINECS	Contact for details

Quality Control

Our (S)-(-)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.