Description

2,2'-Bis(Dicyclohexylphosphino)-1,1'-Biphenyl is a specialized, high-value organophosphorus ligand widely used in homogeneous catalysis. Its primary value lies in its exceptional electron-donating properties and steric bulk, which are critical for modulating the activity and selectivity of transition metal catalysts. This ligand is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for demanding cross-coupling reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations.

Application

• As a key ligand in palladium-catalyzed cross-coupling reactions, including Suzuki, Negishi, and Buchwald-Hartwig amination for C-N and C-C bond formation.
• Enabling highly selective catalytic processes in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Used in the development and scale-up of agrochemicals and advanced materials where precise molecular architecture is required.
• Facilitating academic and industrial R&D in novel catalytic systems and methodology development.
• Employed in asymmetric hydrogenation and other chiral transformations when used in conjunction with appropriate metal centers.
• Serving as a critical component in catalyst kits and screening libraries for high-throughput experimentation (HTE) in drug discovery.

Basic Information

Product Name	2,2'-Bis(Dicyclohexylphosphino)-1,1'-Biphenyl
CAS No.	255897-36-0
Molecular Formula	C36H48P2
Molecular Weight	542.70 g/mol
Synonyms	Dicyclohexyl(2-biphenylyl)phosphine; DtBPF; 2,2'-Bis(dicyclohexylphosphino)biphenyl; 1,1'-Biphenyl, 2,2'-bis(dicyclohexylphosphino)-; Biphenyl-2,2'-diylbis(dicyclohexylphosphine); DavePhos (common trade name for related ligands, sometimes used generically); DtBuPF (common abbreviation); DcyPB
EINECS	Contact for details

Quality Control

Every batch of 2,2'-Bis(Dicyclohexylphosphino)-1,1'-Biphenyl is produced and tested under strict quality management protocols to ensure high purity and consistent performance. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should only be opened in an inert glovebox or under a positive pressure of inert gas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.