Description

(2S)-1-Methyl-2-Azetidinecarboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a four-membered azetidine ring. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, receptor antagonists, and other biologically active molecules.
• Peptidomimetics Research: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and binding affinity.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of new chiral herbicides or plant growth regulators.

Basic Information

Product Name	(2S)-1-Methyl-2-Azetidinecarboxylic Acid
CAS No.	255882-95-2
Molecular Formula	C5H9NO2
Molecular Weight	115.13 g/mol
Synonyms	(S)-1-Methylazetidine-2-carboxylic acid; L-1-Methylazetidine-2-carboxylic acid; (2S)-1-Methylazetidine-2-carboxylic acid; 1-Methyl-L-azetidine-2-carboxylic acid; Azetidine-2-carboxylic acid, 1-methyl-, (2S)-; (S)-1-Methyl-2-carboxyazetidine; 255882-95-2
EINECS	Contact for details

Quality Control

Our (2S)-1-Methyl-2-Azetidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.