Description

2-Azetidinecarboxylic Acid, 1-(Chloroacetyl)-, (2S)- (9Ci) is a high-value, stereochemically defined azetidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its core value lies in enabling the construction of complex molecular architectures with precise stereochemical control, which is paramount for developing bioactive compounds. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-lactam antibiotics, protease inhibitors, and other novel therapeutic agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with specific stereochemical requirements for enhanced activity.
• Peptidomimetics & Bioactive Molecule Design: The azetidine ring serves as a constrained scaffold in designing peptide analogs and other bioactive molecules to improve metabolic stability and binding affinity.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes for studying enzyme mechanisms and biological pathways.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: Can be utilized in the preparation of chiral ligands or organocatalysts for enantioselective transformations.
• Material Science Research: Potential monomer or precursor for specialized polymers with unique ring-strain properties.

Basic Information

Product Name	2-Azetidinecarboxylic Acid, 1-(Chloroacetyl)-, (2S)- (9Ci)
CAS No.	255882-89-4
Molecular Formula	C6H8ClNO3
Molecular Weight	177.59 g/mol
Synonyms	(2S)-1-(Chloroacetyl)azetidine-2-carboxylic acid; L-Azetidine-2-carboxylic acid, 1-(chloroacetyl)-; 1-Chloroacetyl-L-azetidine-2-carboxylic acid; (S)-1-(Chloroacetyl)azetidine-2-carboxylic acid; 1-(Chloroacetyl)azetidine-2-carboxylic acid, (S)-; Azetidine-2-carboxylic acid, 1-(chloroacetyl)-, (2S)-; 255882-89-4; (S)-Azetidine-2-carboxylic acid 1-(chloroacetyl) derivative
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarboxylic Acid, 1-(Chloroacetyl)-, (2S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.