Description

2-(Dicyclohexylphosphino)-2'-Methoxybiphenyl is a specialized, air-stable monodentate phosphine ligand widely used in transition metal catalysis. Its core value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern synthetic organic chemistry. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries seeking to develop novel compounds and optimize manufacturing processes.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings for C–N and C–C bond formation.
• Pharmaceutical Intermediate Synthesis: Used in the scalable production of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Manufacturing: Facilitates the synthesis of novel herbicides, fungicides, and insecticides with improved efficacy.
• Materials Science Research: Employed in the development of organic light-emitting diodes (OLEDs), conductive polymers, and liquid crystals.
• Academic & Industrial R&D: A valuable tool for method development and exploring new catalytic transformations in laboratory settings.
• Fine Chemical Production: Enables the synthesis of specialty chemicals, flavors, and fragrances requiring high selectivity.

Basic Information

Product Name	2-(Dicyclohexylphosphino)-2'-Methoxybiphenyl
CAS No.	255835-82-6
Molecular Formula	C25H33OP
Molecular Weight	380.51 g/mol
Synonyms	2-(Dicyclohexylphosphino)-2'-methoxy-1,1'-biphenyl; SPhos; 2-Dicyclohexylphosphino-2'-methoxybiphenyl; 2'-Methoxy-2-(dicyclohexylphosphino)biphenyl; SPhos Ligand; 2-(Dicyclohexylphosphanyl)-2'-methoxybiphenyl; 255835-82-6; Methoxybiphenyldicyclohexylphosphine
EINECS	Contact for details

Quality Control

Our 2-(Dicyclohexylphosphino)-2'-Methoxybiphenyl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥97% (HPLC). Each lot undergoes comprehensive analysis including NMR (1H, 31P), HPLC, and elemental analysis to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat, sparks, and open flame. Due to its sensitivity to oxidation, containers should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.