Description

Dendroaspis Natriuretic Peptide (DNP) is a potent, 38-amino acid peptide hormone originally isolated from the venom of the green mamba snake (*Dendroaspis angusticeps*). This compound is a valuable research tool for studying natriuretic peptide receptors and cardiovascular physiology due to its unique biological activity. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular drug discovery and basic scientific research.

Application

• Cardiovascular Research: A critical reference standard and tool for investigating the natriuretic peptide system, vasodilation, and blood pressure regulation.
• Receptor Binding Studies: Used in competitive binding assays to characterize and study natriuretic peptide receptors (NPR-A, NPR-B, NPR-C).
• Biochemical Pathway Analysis: Employed to elucidate signaling pathways involving cyclic GMP (cGMP) as a second messenger.
• Drug Discovery & Development: Serves as a lead compound or pharmacological probe in the development of novel therapeutics for hypertension and heart failure.
• In Vitro & Ex Vivo Assays: Applied in cell-based assays and isolated tissue preparations to study its biological effects.
• Quality Control & Standardization: Used as an analytical reference standard for the identification and quantification of related peptides.

Basic Information

Product Name	Dendroaspis Natriuretic Peptide
CAS No.	255721-52-9
Molecular Formula	C179H294N56O53S2
Molecular Weight	4055.7 g/mol
Synonyms	DNP; Dendroaspis Natriuretic Peptide (1-38), green mamba; DNP-38; Snake Venom Natriuretic Peptide; Dendroaspis angusticeps natriuretic peptide; DNP (1-38); H-Ser-Asn-Ser-Ser-Gln-Gln-Gln-Gly-Leu-Ser-Lys-Leu-Cys-Asn-Ser-Phe-Gly-Ala-Lys-Ile-Gly-Ala-Met-Ser-Gln-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH (Disulfide bridge: Cys14-Cys28)
EINECS	Contact for details

Quality Control

Our Dendroaspis Natriuretic Peptide is manufactured under strict quality systems suitable for research use. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical results. Specifications can be tailored to meet specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider aliquoting to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.