Description

(-)-Esphos Ligand, 98+% is a high-purity, chiral phosphine ligand widely utilized in asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer intermediates and active pharmaceutical ingredients (APIs). This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for cross-coupling and hydrogenation reactions.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings to construct complex chiral molecules.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of chiral building blocks for drug candidates with high optical purity.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Fine Chemical Production: Enables the commercial-scale manufacture of specialty chemicals, flavors, and fragrances requiring specific chirality.

Basic Information

Product Name	(-)-Esphos Ligand, 98+%
CAS No.	254990-08-4
Molecular Formula	C27H21P
Molecular Weight	376.43 g/mol
Synonyms	(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (S)-BINAP; (S)-(-)-BINAP; (S)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; Esphos; (S)-(–)-1,1'-Binaphthalene-2,2'-diylbis(diphenylphosphine)
EINECS	Contact for details

Quality Control

Our (-)-Esphos Ligand is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, chiral purity, and impurity profile. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.