Description

Ketoconazolen-Oxide is a key pharmaceutical intermediate and chemical entity, primarily recognized for its role in the synthesis of antifungal agents. This compound is critical for ensuring the quality and efficacy of active pharmaceutical ingredients (APIs) in the final drug formulation. It is essential for manufacturers and R&D facilities in the pharmaceutical, agrochemical, and fine chemical sectors who require high-purity building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of antifungal APIs, particularly derivatives of ketoconazole.
• Research & Development: Serves as a crucial reference standard and building block in medicinal chemistry for developing new therapeutic agents.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of antifungal medications.
• Biochemical Research: Employed in studies investigating sterol biosynthesis inhibition and fungal cell membrane mechanisms.
• Fine Chemical Synthesis: Acts as a specialized intermediate in the multi-step synthesis of complex organic molecules.

Basic Information

Product Name	Ketoconazolen-Oxide
CAS No.	254912-65-7
Molecular Formula	C26H28Cl2N4O4
Molecular Weight	531.43 g/mol
Synonyms	Ketoconazole N-Oxide; 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one oxide; cis-1-Acetyl-4-[4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine 1-oxide; Ketoconazole Impurity; Ketoconazole Related Compound
EINECS	Contact for details

Quality Control

Our Ketoconazolen-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.