Description

2,3-Dehydro Ketoconazole CAS NO 254912-63-5 is a key pharmaceutical intermediate and metabolite derived from the antifungal agent ketoconazole. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in antifungal drug development and metabolic pathway analysis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of advanced antifungal agents and related compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify ketoconazole metabolites in biological samples.
• Drug Metabolism & Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, stability, and clearance mechanisms of ketoconazole.
• Impurity Profiling: Serves as a known impurity or degradation product reference in the quality control of ketoconazole active pharmaceutical ingredients (APIs) and finished dosage forms.
• Biochemical Research: Used in enzymatic and receptor-binding studies to investigate the mechanism of action of antifungal drugs.
• Process Development: Employed in the optimization of synthetic routes and scale-up processes for antifungal drug manufacturing.

Basic Information

Item	Detail
Product Name	2,3-Dehydro Ketoconazole
CAS No.	254912-63-5
Molecular Formula	C26H26Cl2N4O3
Molecular Weight	513.42 g/mol
Synonyms	2,3-Didehydroketoconazole; Ketoconazole Impurity F; (2R,4S)-2-(2,4-Dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-4-[(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)carbonyl]-1,3-dioxolane; UNII-6S2M1178V1; Ketoconazole Metabolite; 2,3-Dehydro Ketoconazole Impurity
EINECS	Contact for details

Quality Control

Our 2,3-Dehydro Ketoconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.