Description

2-Hydroxy Nevirapine is a key pharmaceutical intermediate and metabolite of the antiretroviral drug Nevirapine. This compound is of critical importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on antiviral therapies and analytical method development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and research of Nevirapine and its structural analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies for quantifying Nevirapine metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, clearance, and bioavailability of Nevirapine.
• Impurity Standard: Serves as a certified reference material for identification and quantification of related substances in Nevirapine API quality control.
• Academic and Clinical Research: Supports fundamental research into HIV treatment mechanisms and drug resistance studies.
• Process Development: Used in the development and optimization of synthetic routes for antiretroviral drugs.

Basic Information

Product Name	2-Hydroxy Nevirapine
CAS No.	254889-31-1
Molecular Formula	C15H14N4O2
Molecular Weight	282.30 g/mol
Synonyms	11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 2-Hydroxy Derivative; 2-Hydroxy Nevirapine; Nevirapine 2-Hydroxy Metabolite; 2-OH Nevirapine; 11-Cyclopropyl-2-hydroxy-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
EINECS	Contact for details

Quality Control

Our 2-Hydroxy Nevirapine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.