Description

Desmethyl Bosentan is a key pharmaceutical intermediate and metabolite of the endothelin receptor antagonist bosentan. This compound is of significant value in research and development for studying drug metabolism, pharmacokinetics, and for the synthesis of related therapeutic agents. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and bioanalytical method development.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of endothelin receptor antagonists and related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies (LC-MS, HPLC) to quantify drug metabolism and pharmacokinetic (DMPK) profiles.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate the pharmacological activity and metabolic pathways of bosentan.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control and regulatory compliance in active pharmaceutical ingredient (API) manufacturing.
• Preclinical Development: Aids in toxicology and safety assessment studies for new drug candidates targeting the endothelin system.

Basic Information

Product Name	Desmethyl Bosentan
CAS No.	253688-61-8
Molecular Formula	C26H28N2O6S
Molecular Weight	496.58 g/mol
Synonyms	Ro 48-5033; 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide; Bosentan Impurity; Bosentan Metabolite; Desmethyl Bosentan; 2-Pyrimidinamine, N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)benzenesulfonamide
EINECS	Contact for details

Quality Control

Our Desmethyl Bosentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.