Description

Fos-Choline-11, Sol-Grade is a high-purity, synthetic phospholipid analog specifically designed for solubilization applications. This specialized grade is critical for creating stable, clear solutions of membrane proteins and other challenging biomolecules in biochemical and biophysical research. It is an essential reagent for structural biology, drug discovery, and membrane protein studies, where maintaining native conformation and function is paramount. Researchers in pharmaceutical R&D, academic institutions, and contract research organizations rely on its consistent performance for reproducible experimental outcomes.

Application

• Membrane Protein Solubilization & Stabilization: Primary use for extracting and stabilizing integral membrane proteins (e.g., GPCRs, ion channels, transporters) from cell membranes while preserving their native structure and activity.
• Structural Biology Studies: Essential for preparing samples for X-ray crystallography, cryo-electron microscopy (cryo-EM), and nuclear magnetic resonance (NMR) spectroscopy by forming well-ordered lipid-protein complexes.
• Lipid Nanodisc Formation: Used with membrane scaffold proteins (MSPs) or synthetic polymers to create soluble, monodisperse nanodiscs that mimic native lipid bilayers for in vitro studies.
• Drug Discovery Screening: Provides a more physiologically relevant environment for high-throughput screening (HTS) assays targeting membrane-bound receptors and enzymes.
• Reconstitution of Membrane Proteins: Facilitates the functional incorporation of purified membrane proteins into liposomes or other model membrane systems.
• Biophysical Characterization: Enables spectroscopic and thermodynamic analysis of membrane proteins and their interactions with ligands in a soluble state.

Basic Information

Product Name	Fos-Choline-11, Sol-Grade
CAS No.	253678-65-8
Molecular Formula	C16H36NO4P
Molecular Weight	337.43 g/mol
Synonyms	Fos-Choline-11; 1-Undecanoyl-2-hydroxy-sn-glycero-3-phosphocholine; Lyso-Fos-Choline 11; 1-Lauroyl-2-hydroxy-sn-glycero-3-phosphocholine; LPC 11:0; 1-Monolauroylphosphatidylcholine; LysoPC(11:0/0:0); n-Undecanoyl lysophosphatidylcholine
EINECS	Contact for details

Quality Control

Our Fos-Choline-11, Sol-Grade is manufactured under strict quality management systems to ensure the high purity and batch-to-batch consistency required for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We adhere to relevant industry guidelines for research-grade biochemicals to support your compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Solubility (in water)	Clear, colorless solution at specified concentration
Critical Micelle Concentration (CMC)	Provided on COA
Heavy Metals	< 10 ppm
Residual Solvents	Meets ICH guidelines
Bacterial Endotoxins	< 0.25 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.