Description

Propanamide, N - [4 - Fluoro - 2 - (2,2,2 - Trifluoroacetyl)Phenyl] - 2,2 - Dimethyl is a high-value, specialized organic intermediate characterized by its unique trifluoroacetyl and fluoro-substituted aromatic structure. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where its fluorine-containing motifs are prized for modulating biological activity and stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas where fluorinated compounds are advantageous.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve metabolic stability, lipophilicity, and overall efficacy.
• Chemical Research & Development: Used in academic and industrial R&D laboratories for exploring new chemical entities, reaction methodologies, and structure-activity relationships (SAR) in medicinal chemistry.
• Advanced Material Precursor: Potential use in the synthesis of specialty polymers, liquid crystals, or organic electronic materials where its specific aromatic and fluorinated structure can impart desired physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns for client-specific molecules.

Basic Information

Product Name	Propanamide, N - [4 - Fluoro - 2 - (2,2,2 - Trifluoroacetyl)Phenyl] - 2,2 - Dimethyl
CAS No.	253668-35-8
Molecular Formula	C₁₃H₁₃F₄NO₂
Molecular Weight	291.24 g/mol
Synonyms	N-[4-Fluoro-2-(2,2,2-trifluoroacetyl)phenyl]-2,2-dimethylpropanamide; 2,2-Dimethyl-N-[4-fluoro-2-(2,2,2-trifluoroacetyl)phenyl]propanamide; 253668-35-8; 4-Fluoro-2-(2,2,2-trifluoroacetyl)-N-(2,2-dimethylpropanoyl)aniline; Propanamide, 2,2-dimethyl-N-[4-fluoro-2-(2,2,2-trifluoroacetyl)phenyl]-
EINECS	Contact for details

Quality Control

Our production of Propanamide, N - [4 - Fluoro - 2 - (2,2,2 - Trifluoroacetyl)Phenyl] - 2,2 - Dimethyl adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity assay and identity confirmation via IR and NMR spectroscopy, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) documenting all critical quality attributes are provided as standard, guaranteeing traceability and batch-to-batch consistency for your R&D and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.