Description

2-Propyn-1-Ol, 3-(4-Aminophenyl)- (9Ci) is a specialized aromatic alkyne derivative featuring both an amino group and a propargyl alcohol moiety. This unique bifunctional structure makes it a valuable high-purity intermediate for advanced organic synthesis, particularly in the development of complex molecules. It is primarily sought after by pharmaceutical and agrochemical R&D teams for use in click chemistry, cross-coupling reactions, and as a building block for active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those utilizing alkyne-azide cycloaddition (click chemistry) for bioconjugation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that require a functionalized aromatic core.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers, resins, and functional materials.
• Bioconjugation & Probe Development: Utilized for labeling biomolecules (proteins, peptides, nucleic acids) due to its reactive alkyne group, enabling the creation of diagnostic or imaging probes.
• Organic Synthesis Reagent: Acts as a versatile synthon in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira coupling) to construct complex molecular architectures.

Basic Information

Product Name	2-Propyn-1-Ol, 3-(4-Aminophenyl)- (9Ci)
CAS No.	253167-82-7
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	3-(4-Aminophenyl)-2-propyn-1-ol; 4-(3-Hydroxyprop-1-yn-1-yl)aniline; 4-Ethynylaniline derivative; Propargyl alcohol, 3-(4-aminophenyl)-; p-Aminophenylpropargyl alcohol; 1-(4-Aminophenyl)-2-propyn-1-ol; 4-(3-Hydroxy-1-propynyl)aniline; Building block 253167-82-7
EINECS	Contact for details

Quality Control

Our production of 2-Propyn-1-Ol, 3-(4-Aminophenyl)- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and physical characteristics. Our quality systems are designed to support cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider handling and storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.