Description

Z-Nle-Nle-OH is a protected dipeptide building block featuring two norleucine residues. This compound is essential for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, where it provides a hydrophobic, non-natural amino acid sequence to modulate biological activity and stability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery and development projects.

Application

• Peptide Synthesis Intermediate: A crucial building block for the custom synthesis of novel peptide sequences in research and development.
• Pharmaceutical Research: Used in the discovery and development of peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serves as a spacer or linker moiety in the creation of peptide-drug conjugates and other bioconjugates.
• Structure-Activity Relationship (SAR) Studies: Employed to study the effect of hydrophobic, non-natural amino acid incorporation on peptide potency and metabolic stability.
• Biochemical Tool Development: Used to create substrates, inhibitors, or probes for studying protease and other enzyme functions.
• Material Science: A potential monomer for creating specialized bio-inspired polymers and hydrogels with unique properties.

Basic Information

Product Name	Z-Nle-Nle-OH
CAS No.	252573-92-5
Molecular Formula	C₂₁H₃₂N₂O₅
Molecular Weight	392.49 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-L-norleucyl-L-norleucine; Z-L-Nle-L-Nle-OH; Z-Norleucyl-Norleucine; CBZ-Nle-Nle-OH; N-Carbobenzoxy-L-norleucyl-L-norleucine; (2S)-2-[[(2S)-2-[(Phenylmethoxy)carbonylamino]hexanoyl]amino]hexanoic acid; Benzyl N-[(2S)-1-[[(1S)-1-carboxy-4-methylpentyl]amino]-1-oxo-4-methylpentan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Nle-Nle-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.