Description

Amyloid Beta/A4 Protein Precursor770 (667-676) CAS NO 252256-37-4 is a synthetic peptide fragment corresponding to a specific sequence of the amyloid precursor protein (APP). This high-purity peptide is a critical research tool for studying the molecular mechanisms underlying Alzheimer's disease and related neurodegenerative disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on β-amyloid aggregation, toxicity, and biomarker discovery.

Application

• Neuroscience Research: Fundamental studies on amyloid beta peptide formation, aggregation kinetics, and oligomer toxicity.
• Drug Discovery & Screening: Used as a reference standard or target in high-throughput assays to identify and validate potential therapeutic inhibitors of amyloid aggregation.
• Antibody Development & Characterization: Serves as a key antigen for the production and specificity testing of antibodies targeting the APP 667-676 region.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) designed to detect APP fragments or related biomarkers in biological samples.
• Biophysical Studies: Investigation of peptide structure, conformation, and interaction with membranes or other proteins using techniques like NMR, CD spectroscopy, and surface plasmon resonance (SPR).
• Cell Culture & In Vitro Models: Application in cellular models to study the downstream effects of specific APP fragments on neuronal health, signaling pathways, and inflammation.

Basic Information

Product Name	Amyloid Beta/A4 Protein Precursor770 (667-676) CAS NO 252256-37-4
CAS No.	252256-37-4
Molecular Formula	C55H84N14O13
Molecular Weight	1125.3 g/mol
Synonyms	APP(667-676); Amyloid Beta A4 Protein (667-676); Amyloid Precursor Protein 770 Fragment 667-676; KEVMEDHGY; KEVMEDHGY-OH; AβPP770 (667-676); β-Amyloid Precursor Protein 770 (667-676)
EINECS	Contact for details

Quality Control

Every batch of Amyloid Beta/A4 Protein Precursor770 (667-676) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for sensitive research applications. Our quality assurance includes comprehensive analytical characterization using HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each product to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.