Description

Fmoc-D-Glu-Ofm CAS NO 252049-17-5 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled and efficient construction of complex peptides and peptidomimetics, ensuring high coupling yields and minimal racemization. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of D-glutamic acid into peptide chains.
• Pharmaceutical Research & Development: For the synthesis of novel peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Used to create diverse arrays of peptides for high-throughput screening against biological targets.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides used in imaging, diagnostics, and targeted drug delivery systems.
• Academic & Institutional Research: Fundamental studies in peptide structure-activity relationships (SAR) and chemical biology.
• Custom Peptide Service Providers: A critical raw material for companies offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-D-Glu-Ofm
CAS No.	252049-17-5
Molecular Formula	C₂₆H₂₃NO₇
Molecular Weight	461.46 g/mol
Synonyms	Fmoc-D-Glu(OFm)-OH; N-(9-Fluorenylmethoxycarbonyl)-D-glutamic acid 5-fluorenylmethyl ester; Fmoc-D-Glutamic acid γ-fluorenylmethyl ester; Fmoc-D-Glu(O-Fm)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 5-(9H-fluoren-9-ylmethyl) ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-glutamic acid 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-D-Glu(OCh₂Fl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Glu-Ofm is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material suitable for research and cGMP manufacturing under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.