Description

Fmoc-Lys(Me)2-Oh Hcl CAS NO 252049-10-8 is a protected amino acid derivative, specifically an Fmoc-protected dimethyllysine hydrochloride salt, essential for advanced peptide synthesis. This high-purity building block is critical for introducing a modified lysine residue, enabling the study of protein-protein interactions, epigenetic regulation, and the development of novel therapeutic peptides. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs/CDMOs engaged in solid-phase peptide synthesis (SPPS) for drug discovery and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated synthesis of peptides containing dimethylated lysine residues.
• Drug Discovery & Medicinal Chemistry: Used in the research and development of peptide-based therapeutics targeting epigenetic readers and other biological pathways.
• Biochemical Research: Essential for synthesizing histone mimics and other modified peptides to study post-translational modifications like methylation.
• Antibody-Drug Conjugate (ADC) Development: Can be utilized to incorporate specialized linkers or functional handles into peptide components of ADCs.
• Peptide Library Construction: Enables the creation of diverse peptide libraries for high-throughput screening against various biological targets.
• Process Development & Scale-Up: Serves as a critical raw material for contract manufacturing organizations (CMOs) scaling up GMP-grade peptide APIs.

Basic Information

Product Name	Fmoc-Lys(Me)2-Oh Hcl
CAS No.	252049-10-8
Molecular Formula	C25H32N2O5 • HCl
Molecular Weight	477.00 g/mol
Synonyms	Fmoc-Nε,Nε-dimethyl-L-lysine hydrochloride; Nα-Fmoc-Nε,Nε-dimethyl-L-lysine hydrochloride; Fmoc-Lys(Me2)-OH • HCl; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(dimethylamino)hexanoic acid hydrochloride; Fmoc-Dml-OH • HCl; Fmoc-Nε-Me2-L-Lys-OH • HCl; Nα-(9-Fluorenylmethoxycarbonyl)-Nε,Nε-dimethyllysine hydrochloride
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Me)2-Oh Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.