Description

Fmoc-Dab(Z)-Oh CAS NO 252049-08-4 is a protected amino acid derivative, specifically an N-α-Fmoc and side-chain Z-protected L-2,4-diaminobutyric acid. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a diamino acid residue while preventing unwanted side reactions. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and life sciences who require high-purity intermediates for synthesizing complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of peptides containing L-2,4-diaminobutyric acid (Dab).
• Pharmaceutical Research: Used in the development of novel therapeutic peptides, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers due to its reactive side-chain amine (after deprotection).
• Peptidomimetic Design: Facilitates the creation of modified peptide structures with enhanced stability, bioavailability, or specific activity.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: A fundamental reagent for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Fmoc-Dab(Z)-Oh
CAS No.	252049-08-4
Molecular Formula	C26H24N2O6
Molecular Weight	460.48 g/mol
Synonyms	Fmoc-L-Dab(Z)-OH; N-α-Fmoc-N-δ-Z-L-2,4-diaminobutyric acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((benzyloxy)carbonyl)aminobutanoic acid; Fmoc-Dab(Boc)-OH (Note: Different side-chain protection); Fmoc-L-2,4-diaminobutyric acid(Z); Nα-Fmoc-Nγ-Z-L-2,4-diaminobutyric acid; Fmoc-Dab(Z)-OH (L-form); Fmoc-Dab(Z)-OH (L-configuration)
EINECS	Contact for details

Quality Control

Our Fmoc-Dab(Z)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and correct stereochemical integrity, which are critical for successful peptide synthesis. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and other key parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under desiccant or inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.