Description

(S)-Benzyl (2-Oxo-1-(Prop-2-Yn-1-Yl)Pyrrolidin-3-Yl)Carbamate (Wxg00961) is a high-purity chiral building block featuring a pyrrolidinone scaffold with a propargyl substituent and a benzyl carbamate protecting group. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of complex molecules and active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile functional groups for further chemical modification.
• Asymmetric Synthesis: Serves as a valuable precursor for constructing complex, enantiomerically pure heterocyclic compounds.
• Peptidomimetics Research: The pyrrolidinone core is a common motif in the design of peptidomimetics, making this compound useful for developing enzyme inhibitors.
• Chemical Biology Probes: The alkyne (prop-2-yn-1-yl) handle allows for bioorthogonal conjugation via click chemistry (e.g., CuAAC), enabling the creation of probes for target identification and validation.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential drug candidates during late-stage R&D and pre-clinical development.

Basic Information

Product Name	(S)-Benzyl (2-Oxo-1-(Prop-2-Yn-1-Yl)Pyrrolidin-3-Yl)Carbamate (Wxg00961)
CAS No.	251936-15-9
Molecular Formula	C16H18N2O3
Molecular Weight	286.33 g/mol
Synonyms	(3S)-3-[[(Benzyloxy)carbonyl]amino]-1-(2-propyn-1-yl)-2-pyrrolidinone; Benzyl N-[(3S)-2-oxo-1-(prop-2-yn-1-yl)pyrrolidin-3-yl]carbamate; (S)-1-Propargyl-3-(Cbz-amino)-2-pyrrolidinone; (S)-3-(N-Cbz-amino)-1-propargyl-2-pyrrolidinone; WXG00961; Z-3-Amino-1-propargyl-2-pyrrolidinone, N-Cbz protected; (S)-Cbz-3-Amino-1-propargyl-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our (S)-Benzyl (2-Oxo-1-(Prop-2-Yn-1-Yl)Pyrrolidin-3-Yl)Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.