Description

(4-Chloro-3-Fluoro-Phenyl)-Acetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block. Its molecular structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals. This product is essential for R&D chemists and process development scientists in the life sciences sector seeking to introduce specific halogenated phenyl motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the chloro-fluoro substitution pattern enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Organic Electronic Materials: Building block for creating electron-deficient units in organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: A valuable substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research: Used in academic and industrial R&D for exploring new reaction methodologies and creating novel chemical libraries.

Basic Information

Product Name	(4-Chloro-3-Fluoro-Phenyl)-Acetonitrile
CAS No.	251570-03-3
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-(4-Chloro-3-fluorophenyl)acetonitrile; (4-Chloro-3-fluorophenyl)acetonitrile; 4-Chloro-3-fluorobenzyl cyanide; 2-(4-Chloro-3-fluorophenyl)ethanenitrile; 251570-03-3; 4-Chloro-3-fluoro-α-tolunitrile; p-Chloro-m-fluorophenylacetonitrile
EINECS	Contact for details

Quality Control

Every batch of (4-Chloro-3-Fluoro-Phenyl)-Acetonitrile is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical synthesis workflows. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.